Endocrine Abstracts

Aim: Vitamin D insufficiency is associated with an increase in PTH, which might be critical for an increase in bone fragility. However, the role of endogenous PTH in vitamin D insufficiency-induced increase in fracture risk still remains unclear. The present study was performed to examine the relationships among vitamin D insufficiency, bone fragility, PTH and sclerostin, which is produced by osteocytes and inhibits bone formation by inhibiting the Wnt pathway.<p class="ab...

Although over 50 type 2 diabetes (T2D) loci have been identified through genome-wide association studies (GWAS), the vast majority of the genetic predisposition to T2D still remains to be clarified. One explanation is that despite the use of high-throughput genotyping arrays, only a small proportion of genetic variants in the human genome are actually surveyed, especially in non-European populations. We explored the comprehensive catalog of genomic variations provided by the 1...